MicroRNA-4516 in extracellular vesicles-derived mesenchymal stem cells suppressed integrin αV-mediated lung fibrosis
Collectively, the findings of this study indicate that MSC-EVs may represent a promising novel therapeutic strategy to address the pulmonary fibroblast-mediated mechanisms of lung fibrosis.
Authors
- Toshiya Yonekura
- Shinsaku Togo (ORCID: https://orcid.org/0000-0002-6291-9034)
- Motoyasu Kato (ORCID: https://orcid.org/0000-0002-3217-5118)
- Yusuke Ochi (ORCID: https://orcid.org/0000-0002-8937-1523)
- Hiroaki Motomura
- Issei Sumiyoshi (ORCID: https://orcid.org/0000-0002-2558-3439)
- Shun Nakazawa
- Sonoko Uzu
- Kotaro Kadoya
- Hideya Kitamura (ORCID: https://orcid.org/0000-0002-5800-1175)
- Hiroaki Ihara (ORCID: https://orcid.org/0000-0002-1225-6930)
- Takashi Ogura (ORCID: https://orcid.org/0000-0002-7445-270X)
- Junko Watanabe (ORCID: https://orcid.org/0000-0001-8024-108X)
- Kazuaki Hoshi
- Kazuhisa Takahashi
- Tomoya Komatsu
- Izumi Kaneko
Institutions
- Japan Aerospace Exploration Agency (JP)
- Juntendo University (JP)
- Kanagawa Cardiovascular and Respiratory Center (JP)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-08-15
- DOI
- https://doi.org/10.1186/s13287-025-04559-0
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Japan Society for the Promotion of Science