The utility of early gestational OGTT and biomarkers for the development of gestational diabetes mellitus: an international prospective multicentre cohort study
Although the accurate diagnosis of GDM before 24 weeks remains an ongoing discussion, dynamically assessed glucose concentrations during an early OGTT were closely associated with impaired glucose homeostasis and showed good predictive accuracy for later development of GDM as well as the requirement for insulin. These findings may be used to develop a protocol to distinguish between low- and high-risk mothers. Trial registration ClinicalTrials.gov NCT02035059.
Authors
- Heidi Jaksch‐Bogensperger (ORCID: https://orcid.org/0000-0002-6907-7204)
- Eva Dölzlmüller
- Evelyn A. Huhn (ORCID: https://orcid.org/0000-0001-5382-1353)
- Lenka Vokálová (ORCID: https://orcid.org/0009-0003-7703-5666)
- Daniel Eppel
- Grammata Kotzaeridi (ORCID: https://orcid.org/0000-0002-1286-2607)
- Bettina Winzeler (ORCID: https://orcid.org/0000-0001-8305-2700)
- Günther Schäfer
- Andrea Tura (ORCID: https://orcid.org/0000-0003-3466-5900)
- Nicole Ochsenbein‐Kölble (ORCID: https://orcid.org/0000-0002-7691-965X)
- Shane Vontelin van Breda (ORCID: https://orcid.org/0000-0002-4768-3238)
- Christian Göbl (ORCID: https://orcid.org/0000-0002-3922-7443)
- Anne Richter (ORCID: https://orcid.org/0000-0003-4943-9447)
- Elke Bäz
- Irène Hoesli
- Mirjam Kunze (ORCID: https://orcid.org/0000-0003-4064-5930)
- Thorsten Fischer (ORCID: https://orcid.org/0000-0002-9371-4672)
- M Todesco Bernasconi
- Laura Weidinger
- Helena Stach
Institutions
- Universität Hamburg (DE)
- Paracelsus Medical University (AT)
- University Hospital of Bern (CH)
- University Medical Center Freiburg (DE)
- University Hospital of Basel (CH)
- Hospital Base (CL)
- University Hospital of Zurich (CH)
- University Medical Center Hamburg-Eppendorf (DE)
- Neuroscience Institute (IT)
- Salzburger Landeskliniken (AT)
- Kantonsspital Aarau (CH)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Diabetologia
- Published
- 2025-08-16
- DOI
- https://doi.org/10.1007/s00125-025-06517-0
- Citations
- 4
- Primary Topic
- Gestational Diabetes Research and Management
- Type
- article
- Field-Weighted Citation Impact
- 8.23
Funders
- Universität Basel
- Universität Wien
- Medizinische Universität Wien
- European Association for the Study of Diabetes
- Universitätsspital Zürich