CoREST3 exhibits isoform specific expression in Alzheimer’s disease and regulation of HDAC2
Together these data suggest that CoREST3 plays an isoform specific and direct role in repressing HDAC2, with dysregulated CoREST3 expression in AD possibly contributing to altered HDAC2 levels involved in AD pathogenesis.
Authors
- Kelly A. Newell (ORCID: https://orcid.org/0000-0002-1245-5585)
- Mirella Dottori (ORCID: https://orcid.org/0000-0003-0598-4195)
- Greg T. Sutherland (ORCID: https://orcid.org/0000-0003-2493-9736)
- Simon Maksour (ORCID: https://orcid.org/0000-0002-1837-3863)
- Rachelle Balez (ORCID: https://orcid.org/0000-0002-2787-7107)
- Adile Kaban
- Julia Lim
- Lezanne Ooi (ORCID: https://orcid.org/0000-0001-9241-8268)
- Helena Targa Dias Anastacio (ORCID: https://orcid.org/0000-0002-1672-5378)
- Jeremy S. Lum (ORCID: https://orcid.org/0000-0002-2133-9308)
- Samara Walpole (ORCID: https://orcid.org/0000-0003-4442-2515)
- Calista Turner
Institutions
- The University of Sydney (AU)
- University of Wollongong (AU)
Publication Details
- Journal
- BMC Biology
- Published
- 2025-08-15
- DOI
- https://doi.org/10.1186/s12915-025-02349-x
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Motor Neurone Disease Research Institute of Australia
- Neuroscience Research Australia
- University of New South Wales
- University of Wollongong
- National Institutes of Health