Evaluation of stability and potential interference on the α-thalassaemia early eluting peak and immunochromatographic strip test for α-thalassaemia -- <sup>SEA</sup> carrier screening
αEEP showed reliable performance in detecting α<sup>0</sup>-thalassaemia with --<sup>SEA</sup> mutation in all conditions tested, while ICT showed low specificity when Hb F≥2.0 %. These findings support αEEP as a reliable test for routine clinical laboratory use, while cautions should be made for ICT in case of elevated Hb F levels.
Authors
- Lok Ko
- Chun‐Po Steve Fan (ORCID: https://orcid.org/0000-0002-1278-0118)
- Danny Too
- WK Lam (ORCID: https://orcid.org/0000-0001-6454-5729)
- Anskar Yu Hung Leung
- Sze Fai Yip
- Tsz Fung Wong
- Winnie Yim Fong Law
Institutions
- Tuen Mun Hospital (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Clinical Chemistry and Laboratory Medicine (CCLM)
- Published
- 2025-08-16
- DOI
- https://doi.org/10.1515/cclm-2025-0754
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00