The diagnostic value of controlled attenuation parameter (CAP) and magnetic resonance imaging derived proton density fat fraction (MRI-PDFF) for the evaluation of intestinal failure-associated liver steatosis among adult chronic intestinal failure pa
Both MRI-PDFF and CAP demonstrate high diagnostic accuracy in detecting liver steatosis (LFC >5.5 %) in adult CIF patients. Additionally, CAP shows a strong correlation, while MRI-PDFF exhibits an excellent correlation with severity of 1H-MRS-derived LFC. Both non-invasive techniques, may serve a valuable role in routine assessment of steatosis and steatosis severity in this population, potentially improving early diagnosis, monitoring and understanding of IFALD pathogenesis, ultimately improving patient outcomes.
Authors
- Julia W Korzilius (ORCID: https://orcid.org/0000-0002-6584-1172)
- Geert Wanten (ORCID: https://orcid.org/0000-0002-5918-5594)
- Marinette van der Graaf (ORCID: https://orcid.org/0000-0001-7495-987X)
- V.E.L.M. Gillis (ORCID: https://orcid.org/0000-0002-5309-4608)
- Angelique Huijbers (ORCID: https://orcid.org/0000-0002-7194-4602)
Institutions
- Radboud University Nijmegen (NL)
- Radboud University Medical Center (NL)
- Radboud Institute for Molecular Life Sciences (NL)
Publication Details
- Journal
- Clinical Nutrition ESPEN
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1016/j.clnesp.2025.08.016
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00