The diagnostic value of controlled attenuation parameter (CAP) and magnetic resonance imaging derived proton density fat fraction (MRI-PDFF) for the evaluation of intestinal failure-associated liver steatosis among adult chronic intestinal failure pa

Both MRI-PDFF and CAP demonstrate high diagnostic accuracy in detecting liver steatosis (LFC >5.5 %) in adult CIF patients. Additionally, CAP shows a strong correlation, while MRI-PDFF exhibits an excellent correlation with severity of 1H-MRS-derived LFC. Both non-invasive techniques, may serve a valuable role in routine assessment of steatosis and steatosis severity in this population, potentially improving early diagnosis, monitoring and understanding of IFALD pathogenesis, ultimately improving patient outcomes.

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Publication Details

Journal
Clinical Nutrition ESPEN
Published
2025-08-14
DOI
https://doi.org/10.1016/j.clnesp.2025.08.016
Primary Topic
Liver Disease Diagnosis and Treatment
Type
article
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article

The diagnostic value of controlled attenuation parameter (CAP) and magnetic resonance imaging derived proton density fat fraction (MRI-PDFF) for the evaluation of intestinal failure-associated liver steatosis among adult chronic intestinal failure pa

Julia W Korzilius, Geert Wanten, Marinette van der Graaf, V.E.L.M. Gillis et al.
1 links
Clinical Nutrition ESPEN
Liver Disease Diagnosis and Treatment
article

The diagnostic value of controlled attenuation parameter (CAP) and magnetic resonance imaging derived proton density fat fraction (MRI-PDFF) for the evaluation of intestinal failure-associated liver steatosis among adult chronic intestinal failure pa

Julia W Korzilius, Geert Wanten, Marinette van der Graaf, V.E.L.M. Gillis, Angelique Huijbers
article en

Abstract

Both MRI-PDFF and CAP demonstrate high diagnostic accuracy in detecting liver steatosis (LFC >5.5 %) in adult CIF patients. Additionally, CAP shows a strong correlation, while MRI-PDFF exhibits an excellent correlation with severity of 1H-MRS-derived LFC. Both non-invasive techniques, may serve a valuable role in routine assessment of steatosis and steatosis severity in this population, potentially improving early diagnosis, monitoring and understanding of IFALD pathogenesis, ultimately improving patient outcomes.

Clinical Nutrition ESPENVol. 69
Radboud University Nijmegen (NL), Radboud University Medical Center (NL), Radboud Institute for Molecular Life Sciences (NL)
Openalex Percentile: Top 71%
Liver Disease Diagnosis and Treatment
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