MRO/HNRNPU/CCL5 feedback loop amplifies M2 macrophage and breast cancer cell crosstalk to drive progression
These findings reveal a novel MRO/HNRNPU/CCL5 feedback loop in the interaction between M2 macrophages and BC cells, driving BC progression and reshaping the tumor microenvironment. Targeting this feedback loop offers a potential therapeutic strategy for BC.
Authors
- Dahuan Li
- Zhirui Zeng (ORCID: https://orcid.org/0000-0001-9547-9074)
- Tengxiang Chen (ORCID: https://orcid.org/0000-0001-6907-1374)
- Shan Lei (ORCID: https://orcid.org/0000-0003-3789-4186)
- Lu Wang (ORCID: https://orcid.org/0009-0003-6429-0609)
- Wenjing Tang (ORCID: https://orcid.org/0000-0003-2312-1000)
- Shu Liu (ORCID: https://orcid.org/0009-0000-2914-1091)
- Xin Bao
- Huading Tai
Institutions
- Guiyang Medical University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-08-15
- DOI
- https://doi.org/10.1186/s12967-025-06776-w
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00