Activation of peripheral NOP receptors reduces periorbital mechanical allodynia evoked by CGRP in mice
The peripherally restricted NOP agonist showed efficacy similar to the brain-penetrant compound, indicating that peripheral NOP activation is sufficient to alleviate CGRP-evoked PMA. Despite NOP ability to halt Gα<sub>i</sub> recruitment and cAMP increase in cells, further studies are required to confirm that SCs are the cellular site where N/OFQ operates to attenuate the CGRP pro-migraine action.
Authors
- Pierangelo Geppetti (ORCID: https://orcid.org/0000-0003-3797-8371)
- Chiara Sturaro (ORCID: https://orcid.org/0000-0002-2708-9223)
- Matilde Marini (ORCID: https://orcid.org/0000-0002-2199-2905)
- Dane D. Jensen (ORCID: https://orcid.org/0000-0001-6540-2375)
- Girolamo Calò (ORCID: https://orcid.org/0000-0001-5436-959X)
- Chiara Ruzza (ORCID: https://orcid.org/0000-0003-1360-202X)
- Valentina Albanese (ORCID: https://orcid.org/0000-0002-1947-2644)
- Michela Argentieri
- Marie Soukupovà (ORCID: https://orcid.org/0000-0002-0489-1977)
- Nurulain T. Zaveri (ORCID: https://orcid.org/0000-0002-6850-6732)
- Romina Nassini (ORCID: https://orcid.org/0000-0002-9223-8395)
- Davide Malfacini (ORCID: https://orcid.org/0000-0003-4562-9550)
- Francesco De Logu (ORCID: https://orcid.org/0000-0001-8360-6929)
- P. Pola
- Alessia Frezza
Institutions
- University of Padua (IT)
- University of Ferrara (IT)
- Astraea Therapeutics (United States) (US)
- University of Florence (IT)
- New York University (US)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-08-16
- DOI
- https://doi.org/10.1111/bph.70162
- Citations
- 1
- Primary Topic
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Ministero della Salute
- Università degli Studi di Padova
- Università degli Studi di Ferrara