Inferring amyloid pathologies among patients with mild cognitive impairment using phase‒amplitude coupling of electroencephalography: A case‒control study
Theta-high gamma PAC in resting-state EEG can distinguish amyloid PET-positive patients with MCI from PET-negative patients, thereby providing a feasible, noninvasive biomarker for AD pathology. Integrating PAC analysis into routine EEG could improve the early identification of individuals who qualify for DMTs, thereby facilitating timely intervention.
Authors
- Yuto Satake (ORCID: https://orcid.org/0000-0002-9350-3162)
- Daiki Taomoto (ORCID: https://orcid.org/0009-0006-0578-2517)
- Yuki Miyazaki (ORCID: https://orcid.org/0000-0003-4952-0886)
- Masahiro Hata (ORCID: https://orcid.org/0000-0003-3837-1504)
- Kenji Yoshiyama
- Ryohei Fukuma (ORCID: https://orcid.org/0000-0002-3316-9561)
- Hideki Kanemoto (ORCID: https://orcid.org/0000-0003-3662-1469)
- Takufumi Yanagisawa (ORCID: https://orcid.org/0000-0002-2057-0612)
- Haruhiko Kishima (ORCID: https://orcid.org/0000-0002-9041-2337)
- Takashi Suehiro (ORCID: https://orcid.org/0000-0002-1477-4280)
- Manabu Ikeda (ORCID: https://orcid.org/0000-0003-0730-5774)
- Kayako Isohashi (ORCID: https://orcid.org/0000-0002-2081-3020)
- Shun Takahashi (ORCID: https://orcid.org/0000-0002-9049-4694)
- Keiko Matsunaga
Institutions
- Osaka University of Economics (JP)
- Osaka City University (JP)
- Osaka Health Science University (JP)
- Osaka International Cancer Institute (JP)
- Osaka University Hospital (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- International Psychogeriatrics
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1016/j.inpsyc.2025.100132
- Primary Topic
- EEG and Brain-Computer Interfaces
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development