Complex interaction of δ-globin variant HbA <sub>2</sub> -Famagusta combined with β-globin variant Hb Monroe in <i>cis</i> with the HBB:c.-92C>G mutation: hematological characteristics and molecular diagnostic insights
HbMonroe is a β<sup>0</sup>-thalassemic variant affecting splicing and structure, undetectable by standard Hb analysis. Including HbA<sub>2</sub> variants in total HbA<sub>2</sub> quantification is essential for accurate diagnosis and improved genetic counseling in thalassemia-endemic areas.
Authors
- Sitthichai Panyasai (ORCID: https://orcid.org/0000-0002-7589-3849)
- Surada Satthakarn (ORCID: https://orcid.org/0000-0003-0767-7463)
- Wibhasiri Srisuwan
- Thitima Sumphanapai
Institutions
- Burapha University (TH)
- University of Phayao (TH)
Publication Details
- Journal
- Expert Review of Hematology
- Published
- 2025-08-16
- DOI
- https://doi.org/10.1080/17474086.2025.2549379
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Phayao