MYCN-mediated pyroptosis and inflammation in the molecular mechanism of MicroRNA-202-3P promote functional recovery in spinal cord injury
miR-202-3p mitigates SCI by inhibiting neuroinflammation and pyroptosis via MYCN-mediated suppression of the TLR4/NF-κB/NLRP3 signaling pathway. The findings suggest miR-202-3p as a promising candidate for therapeutic intervention, offering dual benefits of reducing secondary injury and promoting functional restoration post-SCI.
Authors
- Haidi Bi
- Ke Huang
- Bowen Shi (ORCID: https://orcid.org/0000-0002-4753-7572)
- Guodong Zhang (ORCID: https://orcid.org/0009-0003-4230-0255)
- Lang Shuai
- Jing Fang
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1016/j.intimp.2025.115349
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00