Endocrine response assessment in HR-positive HER2-negative early breast cancer: concordance of local versus central Ki67 measurements in the WSG ADAPTcycle trial (n = 5292)
When comparing central and local Ki67 assessments in the large multicenter randomized WSG ADAPTcycle trial, we observed similar rates of ET responders. The agreement between local and central Ki67 assessments at BL and post-endocrine treatment was high, but not yet optimal, with the highest concordance observed in AI-treated patients. Incorporating ETR into daily clinical practice together with multigene assays (as used in WSG ADAPT and ADAPTcycle) needs to be supported by clinicopathological markers for therapy decision making and accompanied by quality assurance programs for Ki67 determination.
Authors
- Sherko Küemmel
- M. Just
- Katarzyna Jóźwiak (ORCID: https://orcid.org/0000-0002-9614-6586)
- Ulrike Nitz (ORCID: https://orcid.org/0000-0003-0143-0507)
- Oleg Gluz (ORCID: https://orcid.org/0000-0001-6019-7544)
- Vesna Bjelic‐Radisic (ORCID: https://orcid.org/0000-0002-3749-4775)
- Ronald Kates (ORCID: https://orcid.org/0000-0003-3550-1051)
- Andreas Hartkopf
- Nadia Harbeck (ORCID: https://orcid.org/0000-0002-9744-7372)
- Rachel Wuerstlein (ORCID: https://orcid.org/0000-0001-7268-0840)
- Christian Schem (ORCID: https://orcid.org/0000-0001-8606-3077)
- Christine zu Eulenburg (ORCID: https://orcid.org/0000-0001-9365-5548)
- Michael Hauptmann (ORCID: https://orcid.org/0000-0001-8539-0148)
- M Christgen
- Pauline Wimberger (ORCID: https://orcid.org/0000-0002-7380-577X)
- Moritz Hamann (ORCID: https://orcid.org/0000-0001-8068-9802)
- Marc Thill (ORCID: https://orcid.org/0000-0002-8800-8044)
- Kerstin Lüdtke-Heckenkamp (ORCID: https://orcid.org/0000-0003-3153-6871)
- Kristina Veselinovic
- Michael Braun (ORCID: https://orcid.org/0000-0003-2680-6224)
- Katja Krauss (ORCID: https://orcid.org/0000-0002-8776-6337)
- S. Burmeister (ORCID: https://orcid.org/0000-0003-0888-7606)
- Oliver Hoffmann (ORCID: https://orcid.org/0000-0003-3093-9054)
- Myriam Vincent
- Frank Baehner
- H. Kreipe
- Monika Graeser
- Patrick Schmid
Institutions
- Witten/Herdecke University (DE)
- Universität Hamburg (DE)
- Queen Mary University of London (GB)
- Bethesda Hospital (IN)
- Deutsches Archäologisches Institut, Zentrale (DE)
- Medizinische Hochschule Hannover (DE)
- MSH Medical School Hamburg – University of Applied Sciences and Medical University (DE)
- Dermatologie Freiburg (DE)
- Exact Sciences (United States) (US)
- University Medical Center Hamburg-Eppendorf (DE)
- Essen University Hospital (DE)
- Helios Universitätsklinikum Wuppertal (DE)
- Breast Center (CH)
- University Children's Hospital Tübingen (DE)
- Medizinische Hochschule Brandenburg Theodor Fontane (DE)
- Kliniken Essen-Mitte (DE)
- Rotkreuzklinikum München (DE)
- Agaplesion Markus Hospital (DE)
- University Hospital Ulm (DE)
- University Hospital Carl Gustav Carus (DE)
- Krankenhaus Köln-Holweide (DE)
- Krankenhaus Jerusalem (DE)
- Technische Universität Dresden (DE)
- University of Tübingen (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1016/j.esmoop.2025.105552
- Citations
- 1
- Primary Topic
- Advanced Biosensing Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.81