Impact of resuscitation with 100% oxygen during physiological-based cord clamping or immediate cord clamping on lung inflammation and injury
The appropriate oxygen level to use during the initial resuscitation of preterm infants during delayed cord clamping/physiological based cord clamping is not known. We found that providing prolonged high oxygen during physiological based cord clamping to preterm lambs does not protect the preterm lung from inflammation, injury or oxidative stress compared to immediate cord clamping. The use of prolonged high oxygen during the initial resuscitation of preterm newborns should be avoided irrespective of what cord clamping strategy is being used.
Authors
- Alison Thiel
- Stuart B. Hooper (ORCID: https://orcid.org/0000-0003-1676-4825)
- Georg Marcus Schmölzer (ORCID: https://orcid.org/0000-0001-9798-2415)
- Robert Galinsky (ORCID: https://orcid.org/0000-0002-6374-9372)
- Graeme R. Polglase (ORCID: https://orcid.org/0000-0002-8906-614X)
- Nhi T. Tran (ORCID: https://orcid.org/0000-0002-0396-9760)
- E Vandenberg (ORCID: https://orcid.org/0000-0002-2458-1618)
- Calum T. Roberts (ORCID: https://orcid.org/0000-0002-9111-5027)
- Martin Kluckow (ORCID: https://orcid.org/0000-0003-1875-7530)
- Shiraz Badurdeen (ORCID: https://orcid.org/0000-0002-3362-6435)
- Arjan B. te Pas (ORCID: https://orcid.org/0000-0001-7831-8797)
- Zoe Johnson
- Andrew Gill (ORCID: https://orcid.org/0000-0003-0212-3103)
- E Cannata (ORCID: https://orcid.org/0009-0000-9513-0075)
- Hui Lü (ORCID: https://orcid.org/0000-0001-9184-2788)
- Valerie A. Zahra
- Zoe Poulos
Institutions
- The University of Sydney (AU)
- University of Alberta (CA)
- The University of Western Australia (AU)
- Leiden University Medical Center (NL)
- Royal North Shore Hospital (AU)
- Mercy Hospital for Women (AU)
- Hudson Institute of Medical Research (AU)
- Royal Alexandra Hospital (CA)
- Monash Children’s Hospital (AU)
- Monash University (AU)
Publication Details
- Journal
- Pediatric Research
- Published
- 2025-08-15
- DOI
- https://doi.org/10.1038/s41390-025-04285-6
- Citations
- 2
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- National Heart Foundation of Australia
- State Government of Victoria
- Medical Research Council
- National Health and Medical Research Council