Anti-MDA5 antibody IgG1 subtype is associated with rapidly progressive interstitial lung disease in anti-MDA5-positive dermatomyositis
Elevated anti-MDA5 IgG1 titers are strongly related to RP-ILD in MDA5<sup>+</sup> DM and function as an important marker for early detection of individuals at high risk. Combining anti-MDA5 IgG1 levels with NLR further enhances predictive accuracy for RP-ILD, offering a practical approach for clinical monitoring and early intervention.
Authors
- Hanxiao You (ORCID: https://orcid.org/0000-0001-6998-5934)
- Wenfeng Tan (ORCID: https://orcid.org/0000-0002-5160-2023)
- Lingxiao Xu (ORCID: https://orcid.org/0000-0003-3418-0727)
- C. Lv (ORCID: https://orcid.org/0000-0001-7920-509X)
- Yulu Qiu
- Yue Wang (ORCID: https://orcid.org/0000-0002-6712-066X)
- Lei Wang (ORCID: https://orcid.org/0000-0003-2172-4406)
- Yun Wu (ORCID: https://orcid.org/0000-0002-6343-3036)
- Yujing Zhu (ORCID: https://orcid.org/0009-0001-7993-4281)
- Fang Wang (ORCID: https://orcid.org/0000-0002-8808-8531)
Institutions
- Xuzhou Medical College (CN)
- Huaian First People’s Hospital (CN)
- Second People’s Hospital of Huai’an (CN)
- Jiangsu Province Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Orphanet Journal of Rare Diseases
- Published
- 2025-08-15
- DOI
- https://doi.org/10.1186/s13023-025-03921-y
- Citations
- 2
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Science and Technology Support Program of Jiangsu Province