Longitudinal assessment of migraine burden in resistant and refractory migraine – Data from the prospective REFINE study
Over six months, ~ 40% of ResM and ~ 30% of RefM individuals improved to NRNRM, while ~ 20% of NRNRM developed treatment resistance after receiving care in tertiary headache centers. Participants with ResM had a better prognosis than those with RefM. While both ResM and RefM reflect high migraine disability burden, they might present relevant differences in their management and prognosis.
Authors
- Umberto Pensato (ORCID: https://orcid.org/0000-0002-4042-4735)
- Gianmarco Iaccarino (ORCID: https://orcid.org/0000-0002-9797-1422)
- Paolo Martelletti (ORCID: https://orcid.org/0000-0002-6556-4128)
- Marta Carnovali (ORCID: https://orcid.org/0000-0002-2292-5288)
- Loukia Apostolakopoulou (ORCID: https://orcid.org/0000-0001-7995-2124)
- Isabel Pavão Martins (ORCID: https://orcid.org/0000-0002-9611-7400)
- Christian Lampl (ORCID: https://orcid.org/0000-0003-1756-1181)
- Jurgita Vainauskienė
- William David Wells-Gatnik (ORCID: https://orcid.org/0009-0002-5564-2783)
- Jakob Paungarttner
- Mark Braschinsky (ORCID: https://orcid.org/0000-0002-3457-0242)
- Patricia Pozo‐Rosich (ORCID: https://orcid.org/0000-0003-0796-4702)
- Margarita Sánchez del Río (ORCID: https://orcid.org/0000-0001-7724-2890)
- Zaza Katsarava (ORCID: https://orcid.org/0000-0002-9932-1159)
- Kristina Ryliškienė (ORCID: https://orcid.org/0000-0001-9596-1733)
- Simona Sacco (ORCID: https://orcid.org/0000-0003-0651-1939)
- Valeria Caponnetto (ORCID: https://orcid.org/0000-0003-4573-6110)
- Albert Muñoz‐Vendrell (ORCID: https://orcid.org/0000-0001-8221-865X)
- Raquel Gil‐Gouveia (ORCID: https://orcid.org/0000-0002-4256-4256)
- Marta Waliszewska‐Prosół (ORCID: https://orcid.org/0000-0002-9074-2803)
- Aynur Özge (ORCID: https://orcid.org/0000-0003-2797-2398)
- Martino Gentile
- Raffaele Ornello (ORCID: https://orcid.org/0000-0001-9501-4031)
- Renato Oliveira (ORCID: https://orcid.org/0000-0003-1181-1418)
- Agnese Onofri (ORCID: https://orcid.org/0000-0002-9697-0970)
- Chiara Rosignoli (ORCID: https://orcid.org/0009-0003-5241-9655)
- Sławomir Budrewićz (ORCID: https://orcid.org/0000-0002-2044-6347)
- Fabrizio Vernieri (ORCID: https://orcid.org/0000-0002-9594-9336)
- Maria Pia Prudenzano (ORCID: https://orcid.org/0000-0001-9259-8158)
- Dimos D. Mitsikostas (ORCID: https://orcid.org/0000-0002-4691-3388)
- Dilan Bayar Narin
- Olga Sved
Institutions
- Texas Tech University (US)
- Humanitas University (IT)
- University of Lisbon (PT)
- Università Campus Bio-Medico (IT)
- Vilnius University (LT)
- National and Kapodistrian University of Athens (GR)
- Universidade Católica Portuguesa (PT)
- University of L'Aquila (IT)
- Tartu University Hospital (EE)
- Wroclaw Medical University (PL)
- Hospital da Luz (PT)
- Unitelma Sapienza University (IT)
- Clinica Universidad de Navarra (ES)
- Eginition Hospital (GR)
- Campus Bio Medico University Hospital (IT)
- IRCCS Humanitas Research Hospital (IT)
- Mersin Üniversitesi (TR)
- University of Duisburg-Essen (DE)
- Sapienza University of Rome (IT)
- Texas Tech University Health Sciences Center (US)
Publication Details
- Journal
- The Journal of Headache and Pain
- Published
- 2025-08-15
- DOI
- https://doi.org/10.1186/s10194-025-02126-9
- Citations
- 3
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.41
Funders
- Ministero della Salute
- Humanitas Research Hospital