Gene‐specific ctDNA dynamics predict tumour burden and survival outcomes in ESCC: A prospective cohort study
Our findings highlight the dynamic role of ctDNA in reflecting ESCC tumour burden and prognosis. While tumour-agnostic ctDNA analysis showed limited clinical utility, gene-specific mutations (TP53, PIK3CA and PTEN) demonstrated significant prognostic value. Preoperative PTEN ctDNA positivity emerged as a robust predictor of aggressive disease, suggesting its potential for risk stratification and personalised therapeutic strategies in ESCC.
Authors
- Hai Jin (ORCID: https://orcid.org/0000-0003-0430-2834)
- Wen Cheng (ORCID: https://orcid.org/0000-0001-7006-4999)
- Tao Liu (ORCID: https://orcid.org/0000-0003-1451-5251)
- Xiaowei Wang (ORCID: https://orcid.org/0000-0003-0940-1882)
- Mengxing Li (ORCID: https://orcid.org/0000-0002-0044-1856)
- Rentong Gu
Institutions
- Tongji University (CN)
- Second Military Medical University (CN)
- Peking University (CN)
- Changhai Hospital (CN)
- Shanghai Pulmonary Hospital (CN)
- Peking University First Hospital (CN)
- Eastern Hepatobiliary Surgery Hospital (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/ctm2.70446
- Citations
- 2
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality