A Diagnostic Challenge: Palatal Nodules as the First Sign of IgG4-Related Disease
Immunoglobulin G4-related disease (IgG4-RD) is a systemic, immune-mediated fibroinflammatory disorder characterized by tumor-like organ enlargement, dense lymphoplasmacytic infiltrates, and storiform fibrosis.<sup>1</sup> Early diagnosis is challenging when IgG4-RD presents as isolated palatal gland nodules, a rare and frequently overlooked manifestation of oral involvement.
Authors
- Shuangshuang Wu (ORCID: https://orcid.org/0000-0001-7759-0772)
- Zhimin Yan (ORCID: https://orcid.org/0000-0002-0751-7374)
Institutions
- Peking University (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- National Clinical Research (US)
Publication Details
- Journal
- The Journal of Rheumatology
- Published
- 2025-08-15
- DOI
- https://doi.org/10.3899/jrheum.2025-0569
- Primary Topic
- IgG4-Related and Inflammatory Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00