Sepsis Induces Long‐Term Muscle and Mitochondrial Dysfunction due to Autophagy Disruption Amenable by Urolithin A
Mitochondrial and autophagy disruption contributes to long-term muscle dysfunction in human and mouse sepsis survivors. We demonstrate for the first time that sepsis induces an autophagy flux blockade. Urolithin A prevents mitochondrial and muscle impairments both in vivo and in vitro by improving autophagy flux.
Authors
- Jérôme Kluza (ORCID: https://orcid.org/0000-0002-7346-1305)
- Sylvain Normandin (ORCID: https://orcid.org/0009-0000-3223-7289)
- Gaëlle Grolaux (ORCID: https://orcid.org/0000-0002-7402-6786)
- Nicolas Barois (ORCID: https://orcid.org/0000-0002-5057-1931)
- Marie Frimat (ORCID: https://orcid.org/0000-0002-7461-8298)
- Raphaël Favory (ORCID: https://orcid.org/0000-0001-7772-2608)
- Bruno Bastide (ORCID: https://orcid.org/0000-0002-7544-463X)
- Frédéric Daussin (ORCID: https://orcid.org/0000-0002-4168-0044)
- Jimmy Vandel (ORCID: https://orcid.org/0000-0003-0189-0220)
- Claire Bourel
- Alina Ghinet (ORCID: https://orcid.org/0000-0001-6468-4331)
- Éric Boulanger (ORCID: https://orcid.org/0000-0002-5204-2849)
- Raphaël Romien
- Estelle Chatelain
- Claire Vincent (ORCID: https://orcid.org/0000-0001-5315-1644)
- William Laine (ORCID: https://orcid.org/0009-0002-2101-5124)
- Valérie Montel (ORCID: https://orcid.org/0000-0002-7286-4209)
- Philippe Marchetti (ORCID: https://orcid.org/0000-0002-4663-6800)
- Sébastien Préau (ORCID: https://orcid.org/0000-0002-8638-7183)
- Benoît Brassart
- Florent Wallet (ORCID: https://orcid.org/0000-0003-3174-6246)
- Alexandre Pierre (ORCID: https://orcid.org/0000-0001-5343-4599)
- Steve Lancel (ORCID: https://orcid.org/0000-0002-3292-5433)
- Jérémy Lemaire (ORCID: https://orcid.org/0000-0002-3777-0506)
- Arthur Durand
- Michael Howsam (ORCID: https://orcid.org/0000-0002-6344-8908)
- Ophélie Not
- Arthur Dubech
Institutions
- Centre National de la Recherche Scientifique (FR)
- Alexandru Ioan Cuza University (RO)
- Inserm (FR)
- Université de Lille (FR)
- Institut Pasteur de Lille (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Lille’s Cardiology Hospital (FR)
- Center for Infection and Immunity of Lille (FR)
- Hôpital Roger Salengro (FR)
- Unité de Recherche Pluridisciplinaire Sport, Santé, Société (FR)
- Groupe Hospitalier de l'Institut Catholique de Lille (FR)
- Hôpital Claude Huriez (FR)
- Institut de Biologie de Lille (FR)
- Université d'Artois (FR)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/jcsm.70041
- Citations
- 3
- Primary Topic
- Dialysis and Renal Disease Management
- Type
- article
- Field-Weighted Citation Impact
- 4.29
Funders
- Université de Lille
- Intensive Care Society
- Agence Nationale de la Recherche
- Société de Réanimation de Langue Française