TRIM6 ablation reverses ICB resistance in MSS gastric cancer by unleashing cGAS-STING-dependent antitumor immunity
Our results elucidate TRIM6-mediated suppression of antitumor immunity as a novel mechanism underlying ICB resistance in MSS gastric cancer, positioning TRIM6 as both a predictive biomarker and therapeutic target for immunologically cold subtypes.
Authors
- Lingmeng Li
- Quansheng Wang (ORCID: https://orcid.org/0000-0002-4676-9478)
- W. Liu (ORCID: https://orcid.org/0000-0002-9844-4296)
- Liyu Huang (ORCID: https://orcid.org/0000-0003-1192-3698)
- Yinan Niu
- Chen Ding (ORCID: https://orcid.org/0000-0001-8673-3464)
- Xuefei Wang (ORCID: https://orcid.org/0000-0002-2645-0953)
- Jingyi Yin (ORCID: https://orcid.org/0009-0009-0349-3262)
Institutions
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- Zhongshan Hospital (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-08-15
- DOI
- https://doi.org/10.1186/s13046-025-03513-5
- Citations
- 4
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 3.19
Funders
- National Natural Science Foundation of China
- Shanghai Jiao Tong University
- Soochow University