Quantitative Iron Measurements in the Basal Ganglia of <scp>NBIA</scp> Patients Using <scp>QSM</scp> : Insights From a Tertiary Center
QSM is a sensitive and noninvasive tool for detecting and quantifying iron accumulation in NBIA. The GP consistently showed the highest susceptibility values across subtypes, emphasizing its significant role in disease pathology. Distinct patterns of iron deposition in different NBIA subtypes may reflect subtype-specific mechanisms with diagnostic and therapeutic relevance. Age-related susceptibility changes were found to be significant, reinforcing the need to account for age when interpreting QSM data. More importantly, QSM may serve as a candidate biomarker for longitudinal disease monitoring in future clinical trials targeting disease-modifying therapies in NBIA.
Authors
- Orkhan Mammadov (ORCID: https://orcid.org/0000-0001-7648-2948)
- Gülay Kır (ORCID: https://orcid.org/0000-0002-2487-359X)
- Alp Di̇nçer (ORCID: https://orcid.org/0000-0001-9158-8353)
- Ercan Köse (ORCID: https://orcid.org/0000-0001-9814-6339)
- Nihan Hande Akçakaya (ORCID: https://orcid.org/0000-0001-8414-4017)
- Sultan Çağırıcı
- Hülya Apaydın (ORCID: https://orcid.org/0000-0003-2808-9353)
- Betül Özdilek (ORCID: https://orcid.org/0000-0003-1608-9882)
- Murat Gültekin (ORCID: https://orcid.org/0000-0002-0609-4269)
- Dilek İnce Günal (ORCID: https://orcid.org/0000-0002-8533-2922)
- Sı̇bel Aylı̇n Uğur İşerı̇ (ORCID: https://orcid.org/0000-0002-5790-6853)
- Banu Özen Barut (ORCID: https://orcid.org/0000-0001-6299-1338)
- Fuat Kaan Aras
- Özge Uygun
- Pınar Topaloğlu
- Alpay Özcan (ORCID: https://orcid.org/0000-0002-3037-2812)
- Zühal Yapıcı (ORCID: https://orcid.org/0000-0002-9349-565X)
- Neşe Tuncer
- Asuman Ali
- Evrim Bozdemir
Institutions
- Koç University (TR)
- Istanbul Bilim University (TR)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Acıbadem University (TR)
- Gülhane Askerî Tıp Akademisi (TR)
- Dr Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi (TR)
- Istanbul University-Cerrahpaşa (TR)
- Bakırköy Dr.Sadi Konuk Eğitim ve Araştırma Hastanesi (TR)
- Kent Hastanesi (TR)
- Kartal Koşuyolu High Specialization Training and Research Hospital (TR)
- Türk Anesteziyoloji ve Reanimasyon Derneği (TR)
- S.B.Ü. Bursa Yüksek İhtisas Eğitim ve Araştırma Hastanesi (TR)
- Boğaziçi University (TR)
- Istanbul Technical University (TR)
- Istanbul Medeniyet University (TR)
- Istanbul University (TR)
- Marmara University (TR)
- Erciyes University (TR)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2025-08-16
- DOI
- https://doi.org/10.1002/acn3.70161
- Primary Topic
- Neurological diseases and metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00