Integrated plasma metabolomic and proteomic analysis uncover the effects and mechanisms of isotretinoin in severe acne
Important DEMs, DEPs and metabolic pathways were identified in this study, which will help clarify the pathogenesis of acneand the potential mechanisms of isotretinoin in the treatment of acne, andidentify novel targets for severe acne treatment and side effect reduction.
Authors
- Yanan Ke
- Jingyao Liang (ORCID: https://orcid.org/0000-0001-9635-9162)
- Yang Hu (ORCID: https://orcid.org/0000-0003-3468-452X)
- Ziyan Chen (ORCID: https://orcid.org/0009-0005-0598-9617)
- Yongtai Liu (ORCID: https://orcid.org/0000-0002-4550-7070)
- Xin Tian (ORCID: https://orcid.org/0000-0001-9601-3751)
- Zeen Yang
- Shujuan Zhang (ORCID: https://orcid.org/0000-0003-0412-7837)
- Jing Zhang (ORCID: https://orcid.org/0000-0001-9372-3723)
- Manqi Xia
Institutions
- The People's Hospital of LinXia (CN)
- Guangzhou Institute of Dermatology (CN)
- Cixian People's Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-08-08
- DOI
- https://doi.org/10.3389/fphar.2025.1590820
- Primary Topic
- Acne and Rosacea Treatments and Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Guangzhou Municipal Science and Technology Project