Heterogeneity and distribution characteristics of tertiary lymphoid structures predict prognostic outcome in esophageal squamous cell carcinoma
This study demonstrates that TLSs and TILs in ESCC are not only prognostically relevant but also spatially heterogeneous. The refined spatial immune profiling across multiple tumor regions improves prognostic stratification and may inform personalized treatment planning in ESCC.
Authors
- Yanping Hu (ORCID: https://orcid.org/0000-0002-5770-2527)
- Qingxin Xia (ORCID: https://orcid.org/0000-0003-0216-9179)
- Chengjuan Zhang (ORCID: https://orcid.org/0000-0002-0702-6890)
- He Zhang (ORCID: https://orcid.org/0000-0002-9540-8935)
- Bin Ma (ORCID: https://orcid.org/0000-0001-5744-9667)
- Tao Wang (ORCID: https://orcid.org/0000-0001-9845-3988)
- Yuxi Chang
- Ruihua Bai
- Jing Yuan (ORCID: https://orcid.org/0000-0002-6936-7615)
- Bing Wei (ORCID: https://orcid.org/0000-0002-3475-7509)
- Junxia Zhang (ORCID: https://orcid.org/0000-0003-1350-9001)
- Tingjie Wang (ORCID: https://orcid.org/0000-0001-9238-0968)
- Xiance Tang
Institutions
- Murdoch University (AU)
- The University of Western Australia (AU)
- Henan Cancer Hospital (CN)
- First Affiliated Hospital of Henan University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1606499
- Citations
- 1
- Primary Topic
- Esophageal Cancer Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Zhengzhou University