Phytochemical inhibition of quorum sensing and biofilm formation by Paederia foetida Linn. against multidrug-resistant Acinetobacter baumannii: An integrated in vitro and in silico investigation
<i>P. foetida</i> extract exhibits potent antibacterial, anti-QS, and antibiofilm activity against MDR <i>A. baumannii</i>, supported by its phytochemical diversity, favorable pharmacokinetics, and strong protein-ligand interactions. These findings suggest its promise as a plant-derived therapeutic aligned with the One Health framework to combat antimicrobial resistance in both human and veterinary medicine.
Authors
- Chul Young Kim (ORCID: https://orcid.org/0000-0002-6988-1059)
- Nitaya Indrawattana (ORCID: https://orcid.org/0000-0003-1571-528X)
- Sirijan Santajit (ORCID: https://orcid.org/0000-0002-1273-2618)
- Techit Thavorasak (ORCID: https://orcid.org/0000-0002-8094-3273)
- Thida Kong-Ngoen (ORCID: https://orcid.org/0000-0002-5756-5833)
- Dararat Horpet (ORCID: https://orcid.org/0009-0008-7972-2407)
- Tae‐gyu Nam (ORCID: https://orcid.org/0000-0002-5292-9335)
- Uttapol Permpoon
Institutions
- Siriraj Hospital (TH)
- Mahidol University (TH)
- Mahidol Oxford Tropical Medicine Research Unit (TH)
- Hanyang University (KR)
- Walailak University (TH)
Publication Details
- Journal
- Veterinary World
- Published
- 2025-08-01
- DOI
- https://doi.org/10.14202/vetworld.2025.2181-2193
- Citations
- 2
- Primary Topic
- Essential Oils and Antimicrobial Activity
- Type
- article
- Field-Weighted Citation Impact
- 2.32
Funders
- Mahidol University
- Walailak University