Untensed fibronectin fibers: a novel hallmark of microthrombi
These findings underscore FnBPA5's unique capacity to discriminate not merely the presence of an abundant ECM molecule within a thrombus, but its distinct physical conformation. FnBPA5 enables the selective detection of microthrombi in coronary arteries by targeting untensed fibronectin fibers, a novel mechanical biomarker of microthrombi. Targeting a protein's physical state with high specificity makes FnBPA5 a promising tool for advanced microthrombi detection and for mechano-therapeutic strategies involving the targeted delivery of therapeutic agents.
Authors
- Nikola Cesarovic (ORCID: https://orcid.org/0000-0001-6744-2928)
- Volkmar Falk (ORCID: https://orcid.org/0000-0002-7911-8620)
- Petra Wolint (ORCID: https://orcid.org/0000-0002-9978-1438)
- Viola Vogel (ORCID: https://orcid.org/0000-0003-2898-7671)
- Arnaud Miéville (ORCID: https://orcid.org/0000-0002-2662-4888)
Institutions
- ETH Zurich (CH)
- Deutsches Herzzentrum der Charité (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-08-08
- DOI
- https://doi.org/10.3389/fcvm.2025.1627917
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Eidgenössische Technische Hochschule Zürich