Effects of oral gavage with periodontal pathogens and plaque biofilm on gut microbiota ecology and intestinal tissue architecture in mice: a mechanistic study
These findings demonstrate that periodontal pathogens induce gut barrier compromise through microbiome-driven immunomodulation, with <i>P. gingivalis</i> exhibiting predominant pro-inflammatory effects.
Authors
- Li Gao (ORCID: https://orcid.org/0009-0001-3818-4218)
- Kun Yang (ORCID: https://orcid.org/0000-0002-5199-0425)
- Yali Yi
- Lian Duan (ORCID: https://orcid.org/0000-0002-3553-6513)
- Yong Li (ORCID: https://orcid.org/0000-0002-6315-2226)
- Song Ge (ORCID: https://orcid.org/0000-0003-4172-1704)
- Lan Huang (ORCID: https://orcid.org/0000-0001-6556-4067)
Institutions
- Zunyi Medical University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-08-08
- DOI
- https://doi.org/10.3389/fcimb.2025.1589055
- Citations
- 5
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 7.33