MRE11 orchestrates porcine oocyte meiotic progression by modulating the spindle assembly checkpoint
These findings demonstrate that Mre11 is essential for porcine oocyte meiotic progression by maintaining normal spindle assembly, actin cytoskeleton dynamics, and SAC activity. DNA damage accumulation following Mre11 inhibition likely contributes to meiotic failure, highlighting its critical role in ensuring oocyte quality.
Authors
- D. Zhang (ORCID: https://orcid.org/0000-0001-9011-2660)
- Yongteng Zhang
- Zubing Cao (ORCID: https://orcid.org/0000-0002-8916-8154)
- Yanfeng Xue (ORCID: https://orcid.org/0000-0003-0257-3825)
- Mianqun Zhang (ORCID: https://orcid.org/0000-0001-5110-174X)
- Hongguo Cao (ORCID: https://orcid.org/0000-0002-5253-8772)
- Yunsheng Li (ORCID: https://orcid.org/0000-0002-4661-9453)
- Fugui Fang (ORCID: https://orcid.org/0000-0003-1057-9493)
- Zaishan Yang (ORCID: https://orcid.org/0009-0002-7729-8434)
Institutions
- Anhui Agricultural University (CN)
- China Coal Technology and Engineering Group Corp (China) (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-08-08
- DOI
- https://doi.org/10.3389/fcell.2025.1635110
- Primary Topic
- Microtubule and mitosis dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Anhui Province