Innate immune pathway activation to modulate mesenchymal stromal cell (MSC) interactions with synovium and cartilage
These findings indicate that joint cells respond differently to factors secreted by TLR or STING pathway activated MSC. The pathways altered were different for each target cell type and no clear pattern of responses was apparent. These results indicate that <i>in vitro</i> modeling of target cell responses to "licensed" MSC can provide new information on the MSC and target cell interactions, though ultimately the functional impacts of activated MSC need to be evaluated using <i>in vivo</i> models.
Authors
- Renata A. Impastato (ORCID: https://orcid.org/0009-0008-6602-102X)
- Peter Linde (ORCID: https://orcid.org/0000-0001-7811-8867)
- Zoë J. Williams (ORCID: https://orcid.org/0000-0002-2852-2914)
- Isabella Sabino (ORCID: https://orcid.org/0000-0002-3513-6480)
- Lynn Marie Pezzanite (ORCID: https://orcid.org/0000-0003-4990-5006)
- Lyndah Chow (ORCID: https://orcid.org/0000-0002-6413-9517)
- STEVEN W. DOW (ORCID: https://orcid.org/0000-0001-5488-9464)
Institutions
- Colorado State University (US)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2025-08-08
- DOI
- https://doi.org/10.3389/fbioe.2025.1605148
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Colorado State University
- Georgia Clinical and Translational Science Alliance
- National Institutes of Health
- National Center for Advancing Translational Sciences