Cistanche tubulosa glycosides ameliorate cognitive decline in APP/PS1 mice via modulation of gut microbiota and fatty acid metabolism: insights from multi-omics and experimental validation
This work uncovers a novel "gut microbiota-fatty acid metabolism-neuroinflammation" axis as the primary mechanism underlying GCT's anti-AD effects. These findings highlight GCT's therapeutic potential and offer new mechanistic insights into how low-bioavailability phytochemicals exert systemic benefits via the gut-brain axis.
Authors
- Yiyi Gong (ORCID: https://orcid.org/0000-0002-5400-9524)
- J. Y. Liu (ORCID: https://orcid.org/0000-0002-7797-9814)
- Rui Li (ORCID: https://orcid.org/0000-0001-5343-3027)
- Jialin Liu (ORCID: https://orcid.org/0000-0002-9450-0772)
- Wei Song (ORCID: https://orcid.org/0000-0002-0983-0823)
- Yi Nan (ORCID: https://orcid.org/0000-0002-5511-9266)
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-08-08
- DOI
- https://doi.org/10.3389/fphar.2025.1662336
- Citations
- 3
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Natural Science Foundation of China
- Peking Union Medical College Hospital
- Peking Union Medical College