Porphyromonas gingivalis hijacks mitophagy and lysosomal function to persist in endothelial cells
Our findings reveal that <i>P. gingivalis</i> may promote its intracellular survival in endothelial cells by initiating PINK1-Parkin-mediated mitophagy and impairing lysosomal function, thereby suppressing xenophagosome formation and xenophagic degradation. This study provides new insights into the mechanisms by which <i>P. gingivalis</i> persists in endothelial cells and its potential role in atherosclerosis progression.
Authors
- Tianhao Chen (ORCID: https://orcid.org/0009-0003-5083-8346)
- Jianmin Huang (ORCID: https://orcid.org/0000-0002-1861-7442)
- Fa‐Ming Chen (ORCID: https://orcid.org/0000-0002-8398-2104)
- Yi Wang (ORCID: https://orcid.org/0009-0006-2692-6890)
- Shengming Xu (ORCID: https://orcid.org/0000-0002-6765-9251)
- Hui Deng (ORCID: https://orcid.org/0000-0002-7426-5146)
- Linlin He (ORCID: https://orcid.org/0000-0002-2254-1233)
- Bin Lü (ORCID: https://orcid.org/0000-0001-9300-4542)
- Xia Fan
- Yubo Hou (ORCID: https://orcid.org/0000-0001-9575-6940)
- Cheng Zheng (ORCID: https://orcid.org/0000-0003-1779-2676)
- Hanxin Que (ORCID: https://orcid.org/0009-0001-9797-2978)
Institutions
- Wenzhou Medical University (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-08-08
- DOI
- https://doi.org/10.3389/fcimb.2025.1613366
- Citations
- 4
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 5.42