Core signature of rejection-associated cytokines and chemokines in endomyocardial biopsies after heart transplantation
A core signature was defined for EMB with histopathologically proven AR, consisting of high concentrations of CXCL9, CXCL10, CCL3, and CCL4. This EMB chemokine signature was clearly distinct from plasma samples, arguing for a local protein microenvironment associated with AR. Further research is also needed with the help of AI to translate the different approaches for the detection and prediction of AR into clinical practice.
Authors
- F. Ius (ORCID: https://orcid.org/0000-0002-8084-3360)
- Christine S. Falk (ORCID: https://orcid.org/0000-0003-1376-7318)
- Christoph Bara
- Adelheid Görler
- Jana Keil
- L. Knigina
- Jenny F. Kühne
- Y. Scheibner
- Kerstin Beushausen
- Lena Radomsky
- Arjang Ruhparwar
Institutions
- Medizinische Hochschule Hannover (DE)
- German Center for Infection Research (DE)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-08-08
- DOI
- https://doi.org/10.3389/fcvm.2025.1612258
- Primary Topic
- Transplantation: Methods and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsches Zentrum für Infektionsforschung
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung