Network pharmacology to explore the novel anti-inflammatory mechanism of naringenin in intestinal ischemia/reperfusion injury
This study demonstrated that Nar inhibited intestinal inflammatory responses by activating YAP, which suppressed p-STAT3 expression, and provided a theoretical basis for Nar's clinical application in intestinal IRI.
Authors
- Min Hou
- Xiao Han (ORCID: https://orcid.org/0000-0002-0544-4351)
- Yanfang Wang (ORCID: https://orcid.org/0000-0002-4926-6868)
- Xiaoxi Li (ORCID: https://orcid.org/0000-0001-5399-5628)
- Zhijun Yang (ORCID: https://orcid.org/0000-0002-6094-0438)
- Zhiguo Tan (ORCID: https://orcid.org/0009-0001-7318-5910)
- Suheng Chen
- Yufang Leng
- Jie Liu (ORCID: https://orcid.org/0000-0002-9740-0056)
Institutions
- Taian City Central Hospital (CN)
- Liaocheng People's Hospital (CN)
- First Hospital of Lanzhou University (CN)
- Anyang Hospital of Traditional Chinese Medicine (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1623080
- Citations
- 1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.81