Hypermethylation of Ring finger protein 41 promoter is associated with early hepatitis B virus-related cirrhosis
Ring finger protein 41 may play a critical role in the pathogenesis of liver cirrhosis, with its methylation status in peripheral blood mononuclear cells demonstrating strong potential as a non-invasive biomarker for early liver cirrhosis detection.
Authors
- Yu‐Chen Fan (ORCID: https://orcid.org/0000-0002-9126-679X)
- Hanxu Zhu
- Kai Wang (ORCID: https://orcid.org/0000-0002-6297-0147)
- Zhezhe Tian
- Shuai Gao (ORCID: https://orcid.org/0000-0002-8444-5415)
- Feng Zhang (ORCID: https://orcid.org/0000-0002-9886-3060)
- Miaomiao Xu (ORCID: https://orcid.org/0000-0002-7307-3409)
Institutions
- Shandong University (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-08-08
- DOI
- https://doi.org/10.3389/fmed.2025.1631990
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shandong University
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province