Multiplexed immune profiling and 3D co-culture assays to assess the individual checkpoint therapy response in head and neck squamous cell carcinoma
This study provides proof-of-principle data suggesting that a combined multiplexed marker profiling and a functional 3D co-culture assay may help to explore predictive ICI response for HNSCC patients in the future. However, extensive studies with larger cohorts are warranted to validate and refine this approach.
Authors
- Anja K. Wege (ORCID: https://orcid.org/0000-0002-8838-0532)
- Mathias Fiedler (ORCID: https://orcid.org/0000-0002-6822-3089)
- Raquel Blazquez (ORCID: https://orcid.org/0000-0002-4464-8189)
- Tobias Ettl (ORCID: https://orcid.org/0000-0002-0549-5351)
- Verena Schweihofer
- Juliane Schikora (ORCID: https://orcid.org/0009-0007-1251-9175)
- Daniela Schulz
- Sina Heimer
- Gero Brockhoff (ORCID: https://orcid.org/0000-0001-8398-8349)
- Richard J. Bauer
Institutions
- Philipps University of Marburg (DE)
- University Hospital Regensburg (DE)
- National Cancer Registry (IE)
- National Medical Research Center of Dentistry and Maxillofacial Surgery (RU)
- University of Regensburg (DE)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-08-08
- DOI
- https://doi.org/10.3389/fonc.2025.1622008
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00