SYNERGISTIC EFFECTS OF ORGANIC ACIDS IN ALCOHOLIC BEVERAGES AND TRPM8 ACTIVATORS IN REDUCING THE HEALTH IMPACTS OF ETHANOL: MECHANISMS AND POTENTIAL APPLICATIONS

The report explores the mechanism of action and biological effect pathways of ethanol, focusing on the analysis of relevant literature published from 2015 to 2023. It investigates the interactions among organic acids, TRPM8 activators, and ethanol using genomic and exposomic approaches, aiming to reveal how these factors collectively mitigate the damage caused by ethanol and assess their overall impact on health. The study integrates human genomic data with environmental exposure data, with particular attention to the effects of organic acids and TRPM8 activators found in baijiu, aiming to uncover key interaction mechanisms and predict biological responses and disease risks. The research emphasizes the significance of genetic variations across different populations, which influence individuals' physiological responses to these substances while also considering the impacts of seasonal and geographical factors. By combining genomics (analyzing individual DNA sequences) and exposomics (studying how environmental factors influence biological pathways), the research offers a comprehensive understanding of gene-environment interactions, thereby improving the prediction of individual responses to ethanol exposure. The study's objectives include identifying key interactions and regulatory mechanisms among these three categories of substances and predicting the physiological and health impacts of such combinations.The analysis will focus on critical mechanistic pathways such as IP3/PLC, NF-κB/iNOS, PI3K/Akt/eNOS, and NO/cGMP pathways, in conjunction with specific genetic variants, such as those in PIK3C2B, NFKB1, and NOS3. This approach provides valuable insights for personalized medicine and potential disease prevention strategies.