Thrombectomy in high-risk pulmonary embolism – device versus thrombolysis: rationale and design of the TORPEDO-NL investigator-initiated, academically-sponsored, multicenter, open-label randomized controlled trial
TORPEDO-NL is the first publicly-funded randomized trial to investigate the effect of CDT treatment specifically in high-risk PE patients. The trial is anticipated to play an important role in revising recommendations for high-risk PE treatment in international guidelines.
Authors
- Ronny M. Schnabel (ORCID: https://orcid.org/0000-0001-8410-332X)
- Thijs Urlings (ORCID: https://orcid.org/0000-0003-0329-3227)
- Martijn F. Boomsma (ORCID: https://orcid.org/0000-0002-7878-0970)
- Nicolas M. Van Mieghem (ORCID: https://orcid.org/0000-0002-2732-1205)
- Jan Albert Vos (ORCID: https://orcid.org/0000-0003-3614-9168)
- Paul L. den Exter (ORCID: https://orcid.org/0000-0002-1543-5731)
- Reinier A Sprenger
- Leon van den Toorn
- Mathilde Nijkeuter (ORCID: https://orcid.org/0000-0003-1406-0699)
- Adriaan O. Kraaijeveld (ORCID: https://orcid.org/0000-0001-5136-5606)
- Hester J. Scheffer (ORCID: https://orcid.org/0000-0001-6298-383X)
- P.R. Tuinman
- Kristien Winckers (ORCID: https://orcid.org/0000-0003-0478-7157)
- Anja Griffioen
- José M. Montero Cabezas (ORCID: https://orcid.org/0000-0002-3851-5195)
- Robert‐Jan van Geuns (ORCID: https://orcid.org/0000-0003-2943-5932)
- Rutger Brans (ORCID: https://orcid.org/0000-0002-7423-5182)
- Merel O. Mol (ORCID: https://orcid.org/0000-0003-2533-2530)
- Marcel M.C. Hovens (ORCID: https://orcid.org/0000-0003-4835-5057)
- Ingrid M. Nijholt (ORCID: https://orcid.org/0000-0003-4820-7505)
- Stavros Konstantinides (ORCID: https://orcid.org/0000-0001-6359-7279)
- Wim J. R. Rietdijk (ORCID: https://orcid.org/0000-0002-2622-7321)
- Corstiaan A. den Uil (ORCID: https://orcid.org/0000-0003-0635-2843)
- Stefan Walen (ORCID: https://orcid.org/0000-0001-6563-1119)
- Sanne de Boer (ORCID: https://orcid.org/0000-0002-5800-0025)
- Martijn Meuwissen (ORCID: https://orcid.org/0000-0002-5421-5205)
- J.M. van Dongen
- Wilhelmina J.E. Stenger
- K.M. Kant
- Frederikus Albertus Klok (ORCID: https://orcid.org/0000-0001-9961-0754)
- Gino M. Kuiper (ORCID: https://orcid.org/0000-0002-4013-7824)
- Dieuwertje Ruigrok (ORCID: https://orcid.org/0000-0002-8868-6857)
- Stefanie Slot (ORCID: https://orcid.org/0000-0003-4871-9674)
- Sjoerd F.M. Jenniskens (ORCID: https://orcid.org/0000-0003-3237-5838)
- Mandy N. Lauw (ORCID: https://orcid.org/0000-0003-0398-3164)
- R. A.H.M. Aarts
- T.T.H. van Leeuwen-Nguyen
- K. Walraven
- Farshad Imani (ORCID: https://orcid.org/0000-0001-6641-9945)
- Thijs E. van Mens (ORCID: https://orcid.org/0000-0002-6520-1597)
- Jenneke Leentjens (ORCID: https://orcid.org/0000-0003-3356-3910)
- Koen M. van de Luijtgaarden (ORCID: https://orcid.org/0000-0001-7165-6718)
- Yvonne M. Ende-Verhaar (ORCID: https://orcid.org/0000-0001-7357-9760)
- Christiaan Lucas Meuwese (ORCID: https://orcid.org/0000-0002-1901-1653)
- Christoffer Krämer (ORCID: https://orcid.org/0000-0002-5426-9334)
- Rutger J. Lely (ORCID: https://orcid.org/0000-0003-1741-9126)
- Dennis A. Kies
- Bram B. van der Meijs
- Ibtihal Al Amri (ORCID: https://orcid.org/0000-0002-2772-7029)
- J. F. Jongkind
- Th. A. Ruys
- S. Levolger
- S. O.J.H. Adriaansens
- A.R. Bijsmans
- N.A.M. Oversier
Institutions
- Radboud University Nijmegen (NL)
- Democritus University of Thrace (GR)
- Utrecht University (NL)
- Johannes Gutenberg University Mainz (DE)
- Heidelberg University (DE)
- Leiden University Medical Center (NL)
- Maastricht University Medical Centre (NL)
- Catharina Ziekenhuis (NL)
- Erasmus MC (NL)
- University Hospital Heidelberg (DE)
- Radboud University Medical Center (NL)
- University Medical Center Utrecht (NL)
- Maastricht University (NL)
- Noordwest Ziekenhuisgroep (NL)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Medisch Centrum Haaglanden (NL)
- St. Antonius Ziekenhuis (NL)
- Amphia Ziekenhuis (NL)
- Amsterdam Neuroscience (NL)
- Maasstad Ziekenhuis (NL)
- Radboud Institute for Molecular Life Sciences (NL)
- Lung Foundation Netherlands (NL)
- Isala (NL)
- Amsterdam University Medical Centers (NL)
- Rijnstate Hospital (NL)
- University of Amsterdam (NL)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Thrombosis Research
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1016/j.thromres.2025.109420
- Citations
- 4
- Primary Topic
- Venous Thromboembolism Diagnosis and Management
- Type
- article
- Field-Weighted Citation Impact
- 7.48
Funders
- Dutch Cardiovascular Alliance
- Penumbra
- ZonMw
- Hartstichting
- Zorginstituut Nederland