Intratumoral microbiome is associated with the response to cancer immunotherapy in lung cancer patients with high PD-L1 expression
This study revealed the specific compositions of intratumoral microbiota as demonstrating relevance to response to ICI therapy in high PD-L1-TPS lung cancer patients. The intratumoral microbiota components <i>Tetrasphaera</i> and <i>Mesorhizobium</i> may have a key role in determining the response to cancer immunotherapy for lung cancer.
Authors
- Fumihiro Shoji (ORCID: https://orcid.org/0000-0002-0636-8696)
- Ryo Toyozawa (ORCID: https://orcid.org/0009-0002-7688-5725)
- T Kawabata
- Masafumi Yamaguchi (ORCID: https://orcid.org/0000-0002-2825-7217)
- Shinichiro Shimamatsu
- Takatoshi Fujishita
- Kensaku Ito
- Keisuke Kosai (ORCID: https://orcid.org/0000-0002-2537-9390)
- Kenichi Taguchi (ORCID: https://orcid.org/0000-0002-6753-2795)
Institutions
- Fukuoka University (JP)
- National Hospital Organization Kyushu Cancer Center (JP)
Publication Details
- Journal
- Immuno-Oncology Technology
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1016/j.iotech.2025.101066
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Uehara Memorial Foundation