Hydrogen gas (H2) delivered by intraperitoneal injection alleviated methionine- and choline-deficient diet-induced metabolic dysfunction–associated steatotic liver disease in mice via inhibiting GSDMD- and GSDME-mediated pyroptosis
H<sub>2</sub> is an anti-pyroptosis gas molecule, intraperitoneal injection of H<sub>2</sub> is a novel therapeutic strategy for MASLD that deserves further investigation.
Authors
- Shuangling Yang (ORCID: https://orcid.org/0000-0002-0450-1174)
- Xinling Chen (ORCID: https://orcid.org/0000-0002-8442-0592)
- Min Dai (ORCID: https://orcid.org/0000-0002-1681-6990)
- Chen Lu (ORCID: https://orcid.org/0000-0002-7781-696X)
- Kangrong Wang
- Jingwen Xu (ORCID: https://orcid.org/0000-0002-2451-8037)
- Yao Deng (ORCID: https://orcid.org/0000-0002-0602-1457)
- Yaxin Zhang (ORCID: https://orcid.org/0000-0002-3550-3164)
- Wenhai Guo (ORCID: https://orcid.org/0000-0002-3426-6013)
- Xiao-Dong Zhang (ORCID: https://orcid.org/0000-0002-1042-8823)
- Yun Chen (ORCID: https://orcid.org/0000-0002-2516-0946)
- Fuman Yan
- Wen Su (ORCID: https://orcid.org/0000-0002-2893-9007)
- Qiuling Li (ORCID: https://orcid.org/0000-0002-6101-8779)
- Haimei Liu (ORCID: https://orcid.org/0000-0002-0079-9444)
- Hongzhi Yang (ORCID: https://orcid.org/0000-0002-9330-1931)
- Wenting Suo
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Sun Yat-sen University (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Anhui Xinhua University (CN)
- Guangzhou Xinhua University
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-08-08
- DOI
- https://doi.org/10.3389/fphar.2025.1575106
- Citations
- 2
- Primary Topic
- Hydrogen's biological and therapeutic effects
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Guangdong Medical Research Foundation