Sperm insulin-like growth factor 2 protein levels: implications for early embryo development
A potential involvement of sperm-delivered IGF2 in early post-fertilization events is suggested, with a limited apparent effect on later embryonic development or ART outcomes. Further investigation into the diagnostic and therapeutic relevance of IGF2 in the context of male-factor infertility is needed.
Authors
- Loredana Leggio (ORCID: https://orcid.org/0000-0003-2948-7644)
- Francesca Mancuso
- Cinzia Lilli
- Scott D. Lundy (ORCID: https://orcid.org/0000-0002-0127-4295)
- Stefano Brancorsini (ORCID: https://orcid.org/0000-0002-8410-7248)
- Qiangzong Yin
- Oliver J. Rando (ORCID: https://orcid.org/0000-0003-1516-9397)
- Aldo Eugenio Calogero (ORCID: https://orcid.org/0000-0001-6950-335X)
- Sandro La Vignera (ORCID: https://orcid.org/0000-0002-7113-2372)
- Antonino Guglielmino
- Sandrine Chamayou (ORCID: https://orcid.org/0000-0002-4185-1923)
- Giovanni Luca (ORCID: https://orcid.org/0000-0003-4445-164X)
- Iva Arato
- Simona Romano (ORCID: https://orcid.org/0000-0002-9401-5814)
- Nunzio Iraci (ORCID: https://orcid.org/0000-0003-2146-9329)
- Rossella Cannarella (ORCID: https://orcid.org/0000-0003-4599-8487)
- Sabrina Farinacci
Institutions
- Cleveland Clinic (US)
- University of Massachusetts Chan Medical School (US)
- University of Perugia (IT)
- University of Catania (IT)
- Centro Medicina della Riproduzione (IT)
Publication Details
- Journal
- Reproductive BioMedicine Online
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1016/j.rbmo.2025.105202
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- American Society for Reproductive Medicine