Clinical andEndoscopicFeatures of PrimaryGastrointestinalLymphoma inAGuatemalan Cohort: A Case Series from Igss

1.1. Background Primary gastrointestinal lymphoma (PGIL) is an uncommon but clinically significant malignancy, often presenting with nonspecific gastrointestinal symptoms that delay diagnosis. General objective: To describe the clinical, endoscopic, and histopathologic features of PGIL in patients treated at a tertiary centre in Guatemala. 1.2. Methods We conducted a retrospective, descriptive, single-centre study of patients diagnosed with diffuse large B-cell lymphoma (DLBCL) or mucosa-associated lymphoid tissue (MALT) lymphoma at the Guatemalan Social Security Institute (IGSS) from January 2023 to January 2025. Variables analysed included demographics, symptoms, endoscopic features, histopathology, Helicobacter pylori status, treatment, and outcomes. 1.3. Results A total of 11 patients were included, with 90.9% DLBCL and 9.1% MALT. Median age was 57 years; 90.9% were male. The most common symptoms were upper GI bleeding (54.5%) and abdominal pain (45.5%). The gastric antrum (36.4%) and small bowel (27.3%) were the most frequent locations. H. pylori was detected in 45.5% of patients. Most received R-CHOP (54.5%), with adjuvant surgery in 36.4%. Mortality was 36.4%, associated with younger age, upper GI bleeding, high-grade histology, elevated Ki-67, and advanced stage. 1.4. Conclusion PGIL shows heterogeneous clinical and endoscopic features, often associated with H. pylori infection. Timely diagnosis and multidisciplinary management are essential to improve prognosis.