Impact of viral load kinetics and recurrent cytomegalovirus infection in kidney transplantation
Patients with a recurrent CMV viremia post-transplant are at exceptionally high risk of transplant failure as measured by graft loss or death, which is determined by both composite risk phenotype and CMV viral load kinetics. Conventional prophylaxis appears to be inadequate to protect these patients from recurrent infection and its serious consequences, and alternative treatment strategies, with continuous long-term monitoring and rapid, effective therapy, are vital to maximize transplant success.
Authors
- John S. Gill (ORCID: https://orcid.org/0000-0002-8837-6875)
- Nancy Matic (ORCID: https://orcid.org/0000-0002-4158-6955)
- Sabina Dobrer
- Paul Keown (ORCID: https://orcid.org/0000-0001-6466-8251)
- Kimberly Davis (ORCID: https://orcid.org/0000-0002-7169-7816)
- Karen Sherwood (ORCID: https://orcid.org/0000-0002-3191-7263)
- James H. Lan (ORCID: https://orcid.org/0000-0002-1710-3810)
Institutions
- University of British Columbia (CA)
- Takeda (United States) (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1600289
- Citations
- 1
- Primary Topic
- Cytomegalovirus and herpesvirus research
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Genome Canada
- Genome British Columbia
- Canadian Institutes of Health Research