Epitope mapping using immunopeptidomics reveals novel immunodominant CD8 T cell epitopes of the AAV9 capsid
Our results represent the first extensive analysis of the naturally presented peptides of the AAV9 capsid. This work provides strategies to improve the detection of the capsid-specific CD8 T cell response in the clinic and reduce vector immunogenicity through the identification of novel CD8 T cell epitopes.
Authors
- Laurent Malherbe
- Marek Prachař (ORCID: https://orcid.org/0000-0002-1797-7147)
- Birgit Klaproth
- Sune Justesen (ORCID: https://orcid.org/0000-0002-3039-2178)
- Victoria Copeland (ORCID: https://orcid.org/0000-0002-2444-5413)
- Robert W. Siegel (ORCID: https://orcid.org/0000-0002-0833-5580)
- Akhila Balasubramanian (ORCID: https://orcid.org/0000-0003-3440-4073)
- Yi Wen (ORCID: https://orcid.org/0000-0003-4862-6427)
Institutions
- Eli Lilly (United States) (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1641289
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00