I<sub>2</sub>-DMSO mediated multi-component cascade cyclization to construct pyrazolo[3,4-<i>b</i>]pyrrolo[3,4-<i>d</i>]pyridine-6-one skeleton
A one-pot synthesis of the pyrazolo[3,4-<i>b</i>]pyrrolo[3,4-<i>d</i>]pyridin-6-one skeleton has been developed using aryl methyl ketones, 3-aminopyrazoles, and enaminamides as substrates. This method features metal-free catalysis and broad substrate compatibility (36 examples). The reaction involves the formation of two C-C and two C-N bonds, while constructing a tetrasubstituted carbon stereocenter bearing a reactive hydroxyl group.
Authors
- Ying Song (ORCID: https://orcid.org/0000-0003-4975-6071)
- You Zhou (ORCID: https://orcid.org/0009-0007-5054-1875)
- An‐Xin Wu (ORCID: https://orcid.org/0000-0001-7673-210X)
- Yong‐Xing Tang
- Lisheng Wang (ORCID: https://orcid.org/0000-0001-6202-5463)
- Chun‐Yan Wu (ORCID: https://orcid.org/0009-0004-1347-7972)
- Yan‐Dong Wu
Institutions
- Central China Normal University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- RSC Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ra04871k
- Primary Topic
- Synthesis and Reactivity of Heterocycles
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Higher Education Discipline Innovation Project