Investigating the Mechanism of Ion Concentration Polarization Within Nanofluidic Hydrogel Membranes: Experiment and Simulation (Adv. Mater. Interfaces 15/2025)

Ion Concentration Polarization In article 2401018, Serdal Kirmizialtin, Yong-Ak Song combine an experimental approach and molecular dynamics simulation to investigate ion concentration polarization (ICP) near the hydrogel membrane inside a nanofluidic system. RNA trapping is optimized at intermediate ionic strength and high ion-selective hydrogel membrane surface charge, driven by coupled electrostatic and hydrodynamic effects. The findings support the design of ICP-enhanced biosensing platforms. Image credit: INMYWORK Studio.