Successful perinatal management in pregnant women with R9 limb-girdle muscular dystrophy and left ventricular ejection fraction of 27%: a case report
A 29-year-old woman with muscle weakness at 26 + 5 weeks of pregnancy was hospitalized for heart failure, and genetic testing revealed that she had R9 limb-girdle muscular dystrophy (LGMDR9). Since LGMDR9 is associated with cardiac and respiratory dysfunction, we promoted fetal lung maturation and performed an emergency cesarean section at 29 + 2 weeks to prevent further deterioration of cardiac function and muscle weakness. This case highlights the importance of choosing the right mode of delivery, timing of delivery, and early genetic testing for LGMDR9 patients.
Authors
- Kai Hu (ORCID: https://orcid.org/0000-0003-2673-6684)
- Jie Mei (ORCID: https://orcid.org/0009-0001-1787-0729)
- Dan Luo (ORCID: https://orcid.org/0000-0001-5291-8428)
- Xiong Liu (ORCID: https://orcid.org/0000-0001-7418-6694)
- Lili Kang (ORCID: https://orcid.org/0000-0003-4266-9055)
- Wenchi Xie (ORCID: https://orcid.org/0009-0007-1180-6607)
- L Huang
Institutions
- University of Electronic Science and Technology of China (CN)
- University of Pittsburgh (US)
- Affiliated Hospital of Southwest Medical University (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-08-08
- DOI
- https://doi.org/10.3389/fmed.2025.1576161
- Primary Topic
- Cardiovascular Issues in Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Department of Science and Technology of Sichuan Province