An explorable model of an adverse outcome pathway of cytokine release syndrome related to the administration of immunomodulatory biotherapeutics and cellular therapies
Beyond a static representation, the CRS Map serves as a dynamic tool for clinical and research applications, allowing researchers and clinicians to explore CRS progression in detail, identify biomarkers, and discover potential therapeutic targets. The map demonstrates stages of CRS progression and shows molecules that can be measured in relevant immunotoxicological assays, as well as potential drug targets for therapeutic intervention of CRS.
Authors
- Charline Sommer (ORCID: https://orcid.org/0000-0002-6390-3878)
- Katherina Sewald (ORCID: https://orcid.org/0000-0002-7804-4527)
- Marek Ostaszewski (ORCID: https://orcid.org/0000-0003-1473-370X)
- Miriam Alb (ORCID: https://orcid.org/0000-0001-6454-9906)
- Muhammad Shoaib (ORCID: https://orcid.org/0000-0002-4854-4635)
- Christina Sakellariou (ORCID: https://orcid.org/0000-0002-2376-7808)
- Alexander Mazein
- Kristin Reiche (ORCID: https://orcid.org/0000-0002-4452-4872)
- Hannah Morgan (ORCID: https://orcid.org/0000-0002-9457-8692)
- Birgit Fogal (ORCID: https://orcid.org/0000-0002-1682-7729)
- Patricia Gogesch (ORCID: https://orcid.org/0000-0003-0025-0782)
- Reinhard Schneider (ORCID: https://orcid.org/0000-0002-8278-1618)
- Vanessa Neuhaus (ORCID: https://orcid.org/0000-0002-0947-4929)
- Venkata Satagopam
- Oxana Lopata (ORCID: https://orcid.org/0000-0003-2852-0115)
- Nhu-Nguyen Pham
- Ethan Perkins
Institutions
- Novartis (Switzerland) (CH)
- Boehringer Ingelheim (Germany) (DE)
- Eurostat (LU)
- University of Bradford (GB)
- University of Luxembourg (LU)
- Lund University (SE)
- LabCorp (United States) (US)
- German Research Centre for Artificial Intelligence (DE)
- Fraunhofer Institute for Toxicology and Experimental Medicine (DE)
- University Hospital Leipzig (DE)
- Universitätsklinikum Würzburg (DE)
- Boehringer Ingelheim (France) (FR)
- Fraunhofer Institute for Cell Therapy and Immunology (DE)
- Center for Scalable Data Analytics and Artificial Intelligence (DE)
- Paul Ehrlich Institut (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1601670
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fraunhofer-Institut für Zelltherapie und Immunologie