Isoflavonoids Modified with Oxygen-containing Heterocycles with One Oxygen Atom

This review summarizes and systematizes the data available in the literature on the synthesis of 4H-chromen-4-ones modified at the 3-position with O-containing heterocycles with one oxygen atom. Classical and modern strategies for the synthesis of natural and synthetic 3-(O-containing)hetarylchromones, versatile synthons used in these syntheses and chemical modifications and transformations both on the chromone ring and heterocyclic rings of different sizes with one oxygen atom of the synthesized 3-hetarylchromones are discussed. Testing data for some types of biological activity including antitumor, antimicrobial, antiviral, hypolipidemic and cardial muscle activity of a number of 3-(O-containing)hetarylchromones and the products of their transformation are also given.