Afucosylated IgG in idiopathic nephrotic syndrome patients with anti-nephrin autoantibodies correlate with disease activity
Our findings confirmed the significance of anti-nephrin autoantibodies as markers of active disease in a small subset of INS patients and showed their presence in urine. ELISA and Immunoprecipitation results correlated. Molecular studies showed that altered IgG fucosylation may contribute to immune-mediated podocyte injury. These insights provide potential biomarkers for disease monitoring and therapeutic targets in INS.
Authors
- Antonella Trivelli
- Lorenzo Gallon (ORCID: https://orcid.org/0000-0002-6094-1027)
- Simona Granata (ORCID: https://orcid.org/0000-0002-3740-7598)
- Giovanni Candiano (ORCID: https://orcid.org/0000-0002-7385-2787)
- Enrico Verrina (ORCID: https://orcid.org/0000-0002-5178-1949)
- Gian Marco Ghiggeri (ORCID: https://orcid.org/0000-0003-3659-9062)
- Francesca Lugani (ORCID: https://orcid.org/0000-0002-4189-8561)
- Edoardo La Porta (ORCID: https://orcid.org/0000-0003-2368-1139)
- Francesca Leone (ORCID: https://orcid.org/0009-0001-6640-8290)
- Andrea Garbarino
- Sonia Spinelli (ORCID: https://orcid.org/0000-0001-9847-4308)
- Giorgio Piaggio (ORCID: https://orcid.org/0000-0003-3814-9997)
- Alberto Magnasco (ORCID: https://orcid.org/0000-0002-1431-4794)
- Gianluigi Zaza (ORCID: https://orcid.org/0000-0002-6004-6196)
- Elena Zocchi (ORCID: https://orcid.org/0000-0001-9477-2615)
- Maria Ludovica Degl’Innocenti (ORCID: https://orcid.org/0000-0002-6126-6780)
- Noemi Rumeo
- Gino Tripodi (ORCID: https://orcid.org/0000-0002-3259-4718)
- Maurizio Bruschi
Institutions
- University of Foggia (IT)
- Istituto Giannina Gaslini (IT)
- University of Illinois Chicago (US)
- Ospedale Annunziata di Cosenza (IT)
- University of Calabria (IT)
- University of Genoa (IT)
Publication Details
- Journal
- Journal of Translational Autoimmunity
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1016/j.jtauto.2025.100307
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00