Formulation development, characterization, and optimization of Eudragit–cinnamon essential oil-based nanoplatform and its efficacy against resistant bacteria

The <i>Klebsiella</i> and <i>Staphylococcus</i> aureus have shown same MIC value of 1.25 μL/ml while <i>E. coli</i> and <i>Pseudomonas aeruginosa</i> shown 0.078 and 0.625 μL/ml respectively. Quadratic polynomial equation depicted that stirring speed exhibited negative effect on the PDI, particle size and encapsulation efficiency. The polymer concentration produced positive effect on the particle size, PDI and encapsulation efficiency of the nanoparticles. The predicted response values were as particle size (Y1) 228.9 nm, PDI (Y2) 0.3 and %EE (Y3) 72.75% which were very close to the actual values of response as particle size (Y1) was 230.4 ± 3.46 nm, PDI (Y2) was 0.293 ± 0.022, and %EE (Y3) was 74.9 ± 2.32%. It was concluded that our prepared formulation can be effectively used treat resistant bacterial infections.