Bacteriological profile and antibiotic sensitivity of germs isolated from blood cultures at the China-Guinea Friendship Hospital of Kipé in Conakry

Introduction: Bacteremia constitutes a major public health problem worldwide, especially when associated with multidrug resistant bacteria. Objective: To determine the bacteriological profile and antibiotic resistance of bacteria isolated from blood cultures at the China-Guinea Friendship Hospital of Kipé in Conakry. Methods: This retrospective study, carried out from January 12 to December 22, 2021. Blood cultures were taken using the Bact/Arlet machine (biomereux, France). Bacterial identification and antibiograms were carried out using the Vitek2 Compact automated system and the API system (bioMérieux, France). Results: Out of a total of eighty (80) blood cultures, forty-five (45) were positive, with a rate of 56.25%. The most represented age group was 31-40 years old with an average age of 36.92±10 years. Gram-positive bacteria were associated with 82.23% of bacteremias, 17.77% for Gram-negative bacteria. The most frequent species were: Escherichia coli (22.23%), Staphylococcus xyloxus (16.23%), Staphylococcus haemolyticus (13.51%), Staphylococcus aureus (13.51%), Staphylococcus hominis (10.81%). A high frequency of resistance of Enterobacteriaceae has been observed towards azetreonam, ceftazidime, gentamicin and tobramycin. On the other hand, the majority of strains were sensitive to imipenem, meropenem and amikacin. Gram-positive bacteria including Staphylococcus xyloxus, strains of Staphylococcus haemolyticus and those of Staphylococcus aureus were resistant to penicillin, Oxacillin, Oxacillin COAG and cefoxtin but sensitive to levofloxacin, nitrofurantoin and linezolid. Conclusion: These results show that Gram-positive bacteria were more frequently associated with bacteremia, although Escherichia coli was in the majority. Finally, a high frequency of multi-antibiotic resistant strains was observed, thus requiring antibiotic therapy based on the results of antibiograms.