Role of ILC2s as Potential Effector Cells of IL25-Mediated Type 2 Inflammation in Chronic Rhinosinusitis with Nasal Polyps in China
ILC2s function as key effector cells of IL-25 in CRSwNP, promoting type-2 inflammation via the STAT3 signaling pathway. Limonin attenuates this response and may serve as a promising therapeutic agent for CRSwNP by targeting IL-25/STAT3-driven ILC2 activation.
Authors
- Ruibiao Song
- Qiuning Yu (ORCID: https://orcid.org/0000-0002-1656-5415)
- Shaochi Wang (ORCID: https://orcid.org/0000-0001-5347-833X)
- Xuyang Liu (ORCID: https://orcid.org/0000-0002-0103-0098)
- Yulin Zhao (ORCID: https://orcid.org/0000-0002-9377-8449)
- Jian Geng (ORCID: https://orcid.org/0009-0005-8057-3929)
- Tingting Liang (ORCID: https://orcid.org/0000-0003-1370-3672)
- Yunpeng Ba
Institutions
- Henan University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-08-01
- DOI
- https://doi.org/10.2147/jir.s534029
- Citations
- 2
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 1.59