PhI(OAc)<sub>2</sub>‐Mediated One‐Pot Synthesis of Pyridoquinazolinones from 2‐Aminobenzaldehydes and 2‐Chloropyridines
A mild, cost‐effective, one‐pot, and metal‐free hypervalent iodine‐mediated protocol for the production of pyridoquinazolinones from 2‐aminobenzaldehydes and 2‐chloropyridines at room temperature has been established. This reported procedure can easily produce biologically active pyridoquinazolinones in a one‐pot manner utilizing readily available starting materials. Operational simplicity, moderate reaction conditions, high atom economy, and high yield are some key features of this protocol. The generation of AcOH and HCl as the only by‐products makes this a cost‐effective procedure for the production of pyridoquinazolinones.
Authors
- Mohammed Issa Alahmdi
- Ali A. Keshk (ORCID: https://orcid.org/0000-0001-9636-0542)
- Meshari A. Alsharif (ORCID: https://orcid.org/0000-0001-5432-7867)
- Mohd Waheed (ORCID: https://orcid.org/0000-0003-2269-9636)
- Omar M. Alatawi
- Humaira Parveen (ORCID: https://orcid.org/0000-0001-8365-0014)
- Sayeed Mukhtar (ORCID: https://orcid.org/0000-0002-5150-9187)
Institutions
- Indian Institute of Technology Roorkee (IN)
- University of Lucknow (IN)
- Umm al-Qura University (SA)
- University of Tabuk (SA)
Publication Details
- Journal
- European Journal of Organic Chemistry
- Published
- 2025-08-09
- DOI
- https://doi.org/10.1002/ejoc.202500591
- Primary Topic
- Quinazolinone synthesis and applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00